From Fairbanks, drive 10 miles north along the Steese Highway to Silver Gulch Brewery, the northernmost brewery in the United States. Next, make the two-hour drive south on the Parks Highway to the community of Healy, which is just 10 miles north of the entrance to Denali National Park and Preserve. Stop in for dinner and a beer tasting at 49th State Brewing Company—the one brewery that rules them all near Denali—and spend the night at one of the local accommodations.
From Healy, drive south on the Parks Highway for three hours to the notoriously quirky town of Talkeetna. Many still insist this small climbing, fishing and mining town was the inspiration for the Alaska-themed TV show "Northern Exposure." Don't miss a chance to people-watch from the outdoor deck at Denali Brewing Company's Twister Creek Restaurant, which sits right on Main Street. Take at least an hour to browse the gift shops featuring locally made crafts up and down Main Street before you hop back in your car and drive another hour and a half south to the farming community of Palmer, where you can catch a tour and tasting at one of the local brewing companies before checking in to your accommodations for the night in either Palmer or nearby Wasilla.
You can either continue south to Anchorage, or depart on the drive back up to Fairbanks and enjoy the scenery along the way.
Have more time to brewery hop through Alaska? Check out this itinerary idea here.