My wife and I had a simply terrific experience in visiting AK this June. We cruised up the Inside Passage from Ketchikan to Skagway, jogged over to Sitka, then sailed to Whittier. From Anchorage, we took the AK RR to Denali National Park.
Denali was spectacular in terms of scenery, the weather (clear and cool), and the wildlife (wolves, snowshoe hares, Dall sheep, ptarmigans). We stayed at the Talkeetna Alaskan Lodge after visiting Denali, and it is certainly to be recommended. The rooms were great, food delicious, and the view across the valley to Mt. McKinley amazing.
Frankly, my wife wasn't too interested in going to Alaska, since she had her heart set on a trip to Scotland. However, after our trip this year, she is busy planning an Autumn vacation to Alaska next hear. Time will tell, but we'll certainly try to get back to Alaska soon.